Disruption of Influenza Virus Properties of Degradation Products of the Virus Particle
نویسندگان
چکیده
Two different precipitating antigens have been extracted from vaccinia virus. One, designated the LS antigen (1), is a protein with two antigenically active groups (2, 3); the other, termed the NP antigen, is a nudeoprotein (4). These two antigens apparently comprise a large proportion of the mass of the virus particle. The soluble complement-fixing antigen of influenza virus is usually extracted from infected tissue and is distinct and separable from the virus particle (5, 6). After ultrasonic vibration of purified influenza virus preparations, an increase in complement-fixing antigen was observed (7), and was attributed to disruption of the virus particle. After treatment of influenza virus particles with ether, hemagglutinating activity can be separated from complement-fixing activity and this has been held to be due to disruption of the virus (8). By this procedure, soluble complement-fixing antigen was released from the particle and small hemagglutinating components were obtained (9).
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